Real-world evidence for the effectiveness and breakthrough of BNT162b2 mRNA COVID-19 vaccine at a medical center in Japan일본 의료 센터에서 BNT162b2 mRNA COVID-19 백신의 효과 및 돌파구에 대한 실제 증거Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, [키워드] Asia Asian BNT162b2 BNT162b2 vaccine breakthrough COVID-19 vaccine delta variant demonstrated Effectiveness Effectiveness. Evidence evidence of hospital hygiene Infection infection control Japan measure mRNA of BNT162b2 Population populations Public hygiene Regulation required retrospective cohort study SARS-CoV-2 Spread Tokyo vaccination Vaccine variant while [DOI] 10.1080/21645515.2021.1984124 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection dynamics revealed by wastewater sequencing analysis and deconvolutionArticle Published on 2022-12-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Accuracy analyses Analysis approach automated B.1.617.2 Berlin can be used changes in circulating computational analysis concern continuous monitoring COVID-19 COVID-19 surveillance Critical dataset detect develop effort environmental monitoring Health highlight identify in silico in-depth analysis include independent individual Infection infection rate Lineage MONITOR Mutation New York City pathogen proportion provide Public Public health risk raw data RBD RNA sequencing SARS-CoV-2 SARS-COV-2 infection sequenced Sequencing Sequencing analysis sequencing data sewage Sewage sampling. shown Support virus viruses VoC while [DOI] 10.1016/j.scitotenv.2022.158931 PMC 바로가기
3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseasesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] animal model animal models Antiviral Cell Cell culture comparable consequence Drug repurposing drug target early phase Ex vivo ex vivo infection Ex vivo infection model Health Host human lung IAV in vitro Infection Inflammatory cytokine Influenza influenza A virus Influenza virus Innate immunity innate immunity. interferon interferon response Intervention introduced lung tissue morbidity and mortality murine outbreak pathophysiological pharmacological platform Respiratory disease respiratory viruses responses SARS-CoV-2 therapy tissue Treatment viral infection viral life cycle viral replication virus virus while [DOI] 10.1080/22221751.2022.2117101 PMC 바로가기
COVAD survey 2 long-term outcomes: unmet need and protocolArticle Published on 2022-12-012022-11-15 Journal: Rheumatology International [Category] 치료제, [키워드] adverse event antiviral drug approach approved Autoimmune diseases baseline booster doses cohorts COVID-19 COVID-19 infection COVID-19 vaccine disease Effect effort groups help Heterologous immune modulation Immunity IMPROVE long-term adverse effects pandemic protocol reduce registries risk syndrome synergistic Tolerability translation unmet need vaccination vaccination. Vaccine while [DOI] 10.1007/s00296-022-05157-6 PMC 바로가기
COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampusArticle Published on 2022-12-012022-11-16 Journal: Apoptosis [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Alter Analysis Apoptosis assist Brain cause cells Central nervous system changes in Characteristics CNS COVID-19 degeneration demonstrated died distribution Effect glial cell glial cells granular hippocampus histological impairment increase in individual mechanisms memory microglia cells MONITOR Morphological morphological change morphology neurodegenerative disorder Neuroinflammation neurological Neuron neuronal neuronal cell organ oxidative stress recent reduce SARS-COV-2 infection Sholl analysis. the disease tissue sample virus while [DOI] 10.1007/s10495-022-01754-9 PMC 바로가기
The long term vaccine-induced anti-SARS-CoV-2 immune response is impaired in quantity and quality under TNFα blockadeArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome alteration analysed anti-SARS-CoV-2 anti-SARS-CoV-2 IgG anti-TNF-α appear Autoimmune Autoimmune diseases blockade bystander Cell changes in chronic inflammatory disease Cohort comparable Control coronavirus COVID-19 Decline drugs Effect Efficacy ELISA flow cytometry groups healthy humoral immune response IgG immune cell populations immune response immunoblot investigated less Live virus Necrosis Neutralization assay neutralize neutralizing antibody neutralizing capacity Older omicron Patient patients plasma Plasma cell recipient reduced response SARS-CoV-2 second vaccination significantly T cell subset titre TNF-α TNFα tumor necrosis factor inhibitors tumor necrosis factor-α vaccination vaccination. Vaccine variants of concern virus VoC was increased while [DOI] 10.1002/jmv.28063 PMC 바로가기
Molecular detection of SARS-COV-2 in exhaled breath at the point-of-needArticle Published on 2022-12-012022-11-15 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Aerosols Analysis Antigen approach approach breath contagious contagiousness detect diagnostics Direct equipment help identify impactor Infection Lab-on-a-chip less limitation molecular Nasopharyngeal swab offer Particle Pathogens patients PCR positive quantification respiratory infections RT-qPCR Saliva SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2. Spread subject temporal dynamics tested Viral load Viral RNA viral shedding Volume while [DOI] 10.1016/j.bios.2022.114663 PMC 바로가기
Immunogenicity and reactogenicity after heterologous prime-boost vaccination with CoronaVac and ChAdox1 nCov-19 (AZD1222) vaccinesCoronaVac 및 ChAdox1 nCov-19(AZD1222) 백신으로 이종 프라임-부스트 백신 접종 후 면역원성 및 반응성Article Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, 진단, [키워드] 95% CI 95% confidence interval Administered age age and sex antibody assigned AZD1222 binding domain booster dose Care ChAdOx1 nCoV-19 Cohort cohorts Combination Concentration control group CoronaVac COVID-19 COVID-19 pandemic effective elicited enrolled finding geometric mean ratio GMR Health Heterologous heterologous prime-boost homologous immune response immunogenicity indicated mass participant primary endpoint prime-boost interval RBD reactogenicity robust Safe the median vaccination Vaccine vaccine administration vaccine combination. while [DOI] 10.1080/21645515.2022.2052525 PMC 바로가기 [Article Type] Article
Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvantsArticle Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 진단, [키워드] abrogated ACE2 addition adjuvant adjuvants Adsorption alum aluminum analysis Antigen approach binding booster Combination Complete conformational Coverage COVID-19 COVID-19 vaccine CpG decrease demonstrated destabilized domain dose ELISA exacerbated facilitate Formulation highlight host cell receptor immune responses immunogenicity IMPROVE in vitro in vivo Interaction interactions mice neutralize neutralizing antibody profile Protein RBD RBD antigen SARS-CoV-2 SARS-CoV-2 pseudovirus spike stability stability profile subunit vaccines temperature the receptor-binding domain Vaccine vaccine. while [DOI] 10.1080/21645515.2022.2079346 PMC 바로가기
Evaluating correlates of protection for mix-match vaccine against COVID-19 VOCs with potential of evading immunityArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] appear Bayesian Beta ChAdOx1 Clinical efficacy Correlate of protection COVID-19 D614G Delta Delta VOC distribution Efficacy ENhance evaluate Evaluating finding Heterologous highlight homologous Immunity inversion Mix-match mRNA-1273 neutralizing antibody omicron pandemic phase 3 trial predicted Predictive previous study provide ranged reduction reductions in strain vaccination Vaccine variant Variant of concern. variants variants of concern VoC VOCs was used while Wuhan [DOI] 10.1016/j.vaccine.2022.10.011 PMC 바로가기